Thermo Fisher Scientific Fas Ligand (FASLG) Monoclonal Antibody (FASLG/4456)
인간 FASLG 단백질을 인식하는 마우스 모노클로날 항체로, IHC(P), IHC(PFA), Peptide Array 등에 사용 가능. 단백질 A/G 정제, 액상 형태로 제공되며 4°C에서 보관. Fas/FasL 시스템 연구 및 세포 사멸 관련 면역 연구에 적합.
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Thermo Fisher Scientific Fas Ligand (FASLG) Monoclonal Antibody (FASLG/4456)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FASLG/4456 |
| Immunogen | Human recombinant FASLG protein fragment (around aa107–222) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD178 (Fas ligand, FasL) is a type-II membrane protein with its N-terminus in the cytoplasm and C-terminus extending extracellularly. Its receptor, FasR, is a member of the TNF and NGF receptor families. Interaction between CD178 and FasR induces apoptosis through receptor oligomerization.
CD178 exists in membrane-bound (45 kD) and soluble (26 kD) forms, the latter released via metalloproteinase cleavage. It is predominantly expressed in activated T-lymphocytes and NK cells, as well as immune-privileged tissues such as testis and eye. Expression has also been observed in thymus, liver, ovary, lung, heart, and kidney.
The Fas/CD178 system is involved in antiviral immune responses, immune regulation, and T cell–mediated cytotoxicity. Altered CD178 concentrations have been associated with atherosclerosis and inflammatory diseases, including hypertension. This system plays roles in various human diseases such as AIDS, hepatitis, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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