Thermo Fisher Scientific TNFRSF13B Monoclonal Antibody (1C4)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
SGLGRSRRGG RSRVDQEERF PQGLWTGVAM RSCPEEQYWD PLLGTCMSCK TICNHQSQRT CAAFCRSLSC RKEQGKFYDH LLRDCISCAS ICGQHPKQCA YFCENKLRSP VNLPPELRRQ RSGEVENNSD NSGRYQGLEH RGSEASPALP GLKLSADQVA LVYS

Target Information

Members of the TNF superfamily regulate immune responses and induce apoptosis. Two novel members, BAFF (also known as BLyS/TALL-1/THANK/zTNF4) and APRIL (TALL-2), have been identified.

• BAFF acts as a B cell activator, inducing proliferation and immunoglobulin secretion.
• APRIL regulates both immunological and non-immunological cell growth.
  Three receptors — BCMA, TACI, and BAFF-R — bind BAFF and APRIL.
  TACI and its ligands regulate humoral immune responses, activate NF-κB and c-Jun N-terminal kinase, and are involved in B cell–associated autoimmune diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.