Thermo Fisher Scientific TRMT12 Monoclonal Antibody (OTI3C10), TrueMAB
TRMT12 단백질을 인식하는 Mouse IgG2a 단일클론 항체. Western blot과 IHC(Paraffin)에서 검증됨. 고순도의 Affinity chromatography 정제 항체로, PBS/BSA/glycerol buffer에 보관. 인간 TRMT12 발현 연구 및 암 관련 단백질 분석에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C10 |
| Immunogen | Full length human recombinant protein of human TRMT12 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TYW2 (also known as TRM12) is an enzyme involved in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine located at the 3′ position adjacent to the anticodon of phenylalanine tRNA, stabilizing codon-anticodon interactions during ribosomal decoding.
TYW2 participates in a multistep enzymatic reaction that ensures accurate translation by stabilizing codon-anticodon base pairing.
Amplification of TYW2 has been observed in multiple breast cancer cell lines, and overexpression (more than 2-fold) was detected in 26 out of 30 breast tumor samples, suggesting a potential role in breast cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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