Thermo Fisher Scientific TRIM28 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1235)

Applications

• Western Blot (WB): Assay-dependent
• ELISA: Assay-dependent
• Immunoprecipitation (IP): Assay-dependent

Product Specifications

Product Specific Information

• Compatible with Direct ELISA

Target Information

The KRAB (Kruppel-associated box) domain is approximately 45 amino acids in length and acts as a transcriptional repression domain found in numerous transcription factors.
Over 220 KRAB-zinc finger protein (KRAB-ZFP) genes have been identified in the human genome. These proteins repress transcription through interactions with KAP-1 (KRAB-associated protein 1), an 835-amino-acid polypeptide containing a RING finger, B boxes, and a PHD finger.
KAP-1 forms complexes with KRAB-domain transcription factors to enhance repression efficiency and interacts directly with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1).
KAP-1 targets KRAZ1 to centromeric heterochromatin regions containing HP1α, thereby regulating transcriptional repression.
Mutations in KAP-1 that bind KRAB but not HP1 lead to random KRAZ1 distribution and strong transcriptional activation.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.