Thermo Fisher Scientific MIP-3 beta Monoclonal Antibody (OTI2A12)
인간 CCL19 단백질(아미노산 22-98)에 특이적인 마우스 모노클로날 항체. IHC(P)에서 1:150 희석으로 사용 가능. 액상 형태로 제공되며, PBS 버퍼에 1% BSA와 50% 글리세롤 포함. -20°C 보관, 동결/해동 반복 피할 것.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–98 of CCL19 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724697 |
Target Information
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is closely related to CCL21, sharing 32% amino acid sequence homology.
CCL19 and CCL21 are mainly expressed by stromal cells in the T cell-rich zones of lymph nodes and are critical mediators of homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs.
They play roles in T cell priming, activation, and recruitment of lymphocytes to inflamed tissue. Both signal through the G protein-coupled receptor CCR7, expressed on T cells and mature dendritic cells.
Although both exhibit similar affinity for CCR7, only CCL19 binding leads to desensitization and internalization of the receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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