Thermo Fisher Scientific HEF1 Polyclonal Antibody
HEF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료 반응성, IHC(P) 검증, 항원 친화 크로마토그래피 정제. 세포 이동성, 성장, 암 관련 신호 연구용. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5111103
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HEF1. Recombinant protein control fragment (Product #RP-102849). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856513 |
Product Specific Information
Immunogen sequence:
WWLCSLHGRQ GIVPGNRVKL LIGPMQETAS SHEQPASGLM QQTFGQQKLY QVPNPQAAPR DTIYQVPPSY QNQGIYQVPT GHGTQEQEVY QVPPS
Target Information
HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis, and oncogenic transformation.
The Cas family of docking proteins are substrates of focal adhesion kinase (FAK) and Src family tyrosine kinases, which are active targets for drug development.
HEF1 protein production increases mRNA transcripts associated with motility, cell transformation, and invasiveness, including metalloproteinases, MLCK, p160ROCK, and ErbBi.
HEF1 overproduction mediates apoptosis in epithelial-derived cell lines such as MCF7 and HeLa.
Overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance, highlighting the role of this protein family in cancer prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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