Thermo Fisher Scientific CD223 (LAG-3) Monoclonal Antibody (3DS223H), FITC, eBioscience
인간 CD223(LAG-3)을 인식하는 단클론 항체로, FITC로 표지되어 유세포 분석(Flow Cytometry)에 적합합니다. 정제된 액상 형태로 제공되며, 4°C 암소 보관이 필요합니다. T세포 활성 조절 연구 및 면역조절 메커니즘 분석에 활용됩니다.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.06 µg)/test
- Publications: View 11 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3DS223H |
| Immunogen | hCD223-FC PFA 4% |
| Conjugate | FITC |
| Excitation/Emission Max | 498/517 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572485 |
Additional Available Formats
- Alexa Fluor 647
- Alexa Fluor 660
- Alexa Fluor 700
- APC, APC-eFluor 780
- Brilliant UV 395, 563, 661, 737, 805
- Brilliant Violet 421, 480, 605, 650, 711, 786
- eFluor 450, 506
- NovaFluor Blue 510, 660-120S
- NovaFluor Red 700
- NovaFluor Yellow 590, 610, 700, 730
- PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436, 600, 645, 702, 780
- Request custom conjugation
Product Specific Information
This 3DS223H monoclonal antibody recognizes human CD223, also known as Lymphocyte Activation Gene 3 (LAG-3).
LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. It binds to MHC class II with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation.
- Expressed on activated T cells (including regulatory T cells) and NK cells
- CD8+ T cells express higher levels than CD4+ T cells
- Coexpression of LAG-3 and CD49b identifies Type 1 regulatory T cells (Tr1 cells)
- Recognizes a formaldehyde-fixed epitope
- Reported for flow cytometric analysis
- Pre-titrated and tested for use at 5 µL (0.06 µg) per test
- Excitation: 488 nm; Emission: 520 nm; Laser: Blue
- 0.2 µm post-manufacturing filtered
Target Information
LAG-3 is a 70-kDa surface glycoprotein of the Ig superfamily with structural homology to CD4.
It binds MHC class II with high affinity and plays a role in downregulating T cell activation and maintaining immune homeostasis.
Surface expression is found on activated T cells, regulatory T cells, and NK cells.
Coexpression with CD49b is a marker for human and mouse Type 1 regulatory T cells (Tr1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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