Thermo Fisher Scientific FALZ/BPTF Polyclonal Antibody
Thermo Fisher Scientific의 FALZ/BPTF Polyclonal Antibody는 인간 시료에 반응하는 토끼 유래 IgG 항체로, IHC 및 IHC(Paraffin) 실험에 적합합니다. BPTF 단백질을 표적하며, 신경퇴행성 질환 연구 및 염색체 리모델링 관련 연구에 활용됩니다.
- 카탈로그번호
- IHC00521x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific FALZ/BPTF Polyclonal Antibody
Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1350 and 1400 of human Fetal Alzheimer Antigen (Bromodomain and PHD Domain Transcription Factor) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Chimpanzee, and Northern white-cheeked gibbon.
Target Information
BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognizes histone H3 tails that are tri-methylated at K4, marking transcriptional start sites of most active genes. It also binds to H3 di-methylated at K4.
BPTF plays a key role in early mouse embryo development, possibly through regulation of the Smad transcription factor pathway. It is expressed at low levels in adult brain and spinal cord but at higher levels in neurodegenerative diseases. Found in amyloid-containing plaques of Alzheimer’s disease brains, and abundantly expressed in fetal brain. Present throughout gray and white matter of the developing spinal cord at 18–22 gestational weeks. Tissue specificity: ubiquitously expressed with highest levels in testis; also present in kidney, liver, and brain, with highest levels in motor cortex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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