Thermo Fisher Scientific FAM111A Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  STQPVDELEG RYFQVEVEKR MVPSAAASQN PESEKRNTCV LREQIVAQYP SLKRESEKII ENFKKKMKVK NGETLFELHR TTFGKVTKNS SSIKVVKLLV RLSDS
• Highest antigen sequence identity to orthologs:
  Mouse – 48%, Rat – 44%

Target Information

Chromosome 11 comprises approximately 135 million base pairs and 1,400 genes, representing about 4% of human genomic DNA. It is dense with gene and disease associations.
The Atm gene on chromosome 11 regulates cell cycle arrest and apoptosis following double-strand DNA breaks. Mutations in Atm cause ataxia telangiectasia.
Blood disorders such as sickle cell anemia and β-thalassemia result from HBB gene mutations.
Mutations in the WT1 gene are linked to Wilms’ tumor, WAGR syndrome, and Denys-Drash syndrome.
Other disorders associated with chromosome 11 defects include Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema, and Smith-Lemli-Opitz syndrome.
The FAM111A gene product has been provisionally designated FAM111A pending further characterization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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