Thermo Fisher Scientific CUEDC2 Monoclonal Antibody (2B11)
Thermo Fisher Scientific의 CUEDC2 Monoclonal Antibody (2B11)는 인간 CUEDC2 단백질을 인식하는 Mouse IgG2b 항체입니다. Western blot 및 ELISA에 적합하며, 고순도 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용되며, -20°C에서 보관을 권장합니다.
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Thermo Fisher Scientific CUEDC2 Monoclonal Antibody (2B11)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B11 |
| Immunogen | CUEDC2 (NP_076945.1, 1–226 a.a) full-length recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of CUEDC2 protein:
MELERIVSAA LLAFVQTHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE NFDMEAFTEM MEAYVPGFAH IPRGTIGDMM QKLSGQLSDA RNKENLQPQS SGVQGQVPIS PEPLQRPEML KEETRSSAAA AADTQDEATG AEEELLPGVD VLLEVFPTCS VEQAQWVLAK ARGDLEEAVQ MLVEGKEEGP AAWEGPNQDL PRRLRGPQKD ELKSFILQKY MMVDSATarget Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation.
CUE domains are present in eukaryotic proteins involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found.
CUEDC2 (CUE domain-containing protein 2) was identified through yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation via the ubiquitin-proteasome pathway.
CUEDC2 also decreases the sumoylation of PR and interacts with IKK-alpha and IKK-beta, reducing NF-kappa-B activation by decreasing IKK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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