Thermo Fisher Scientific Aminoacylase Polyclonal Antibody

Thermo Fisher Scientific Aminoacylase Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji
• Predicted reactivity: Mouse (85%), Rat (86%), Pig (86%), Bovine (87%)
• Store product as a concentrated solution. Centrifuge briefly before opening the vial.

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It functions in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), where expression is often reduced or undetectable.
Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants; read-through transcription also occurs with the upstream ABHD14A gene. A related pseudogene exists on chromosome 18.

Safety and Regulatory Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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