Thermo Fisher Scientific Chk1 Polyclonal Antibody
Chk1 단백질 인산화 효소를 인식하는 염소 유래 폴리클로날 항체. Western blot 및 IP에 사용 가능. 항원 친화 크로마토그래피로 정제. 인간에 반응하며 마우스, 랫에서도 예측 반응. 연구용으로 DNA 손상 반응 연구에 적합.
- 카탈로그번호
- A300161A
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,500–1:15,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 200 and 250 of human Checkpoint Kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in maintaining DNA integrity. It acts as a key mediator in the DNA damage-induced checkpoint network and helps ensure genomic stability under genotoxic stress.
When CHK1 is inhibited, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells remain arrested in the G1 phase. Therefore, CHK1 is considered an attractive therapeutic target for cancer treatment, particularly since about 50% of human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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