Thermo Fisher Scientific eIF3a Recombinant Rabbit Monoclonal Antibody (23GB830)
eIF3a 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot, ICC/IF, Flow cytometry에 적합. 높은 특이성과 재현성을 제공하며, 연구용으로 단백질 번역 개시 복합체 분석에 활용 가능.
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Thermo Fisher Scientific eIF3a Recombinant Rabbit Monoclonal Antibody (23GB830)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB830 |
| Immunogen | A synthetic peptide of human eIF3A (1100–1154AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773).
The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).
It stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex also contributes to disassembly and recycling of post-termination ribosomal complexes, preventing premature joining of the 40S and 60S ribosomal subunits.
Additionally, eIF-3 specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including those regulating cell cycle, differentiation, and apoptosis, using distinct RNA stem-loop binding modes for translational activation or repression (PubMed:25849773, PubMed:27462815).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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