Thermo Fisher Scientific SH3PXD2A Polyclonal Antibody
SH3PXD2A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인베도포디아 형성 및 암세포 침습 관련 연구에 활용되며, 고순도 친화 크로마토그래피로 정제된 1 mg/mL 액상 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SH3PXD2A (Accession Q5TCZ1), corresponding to amino acid residues V105–D155 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853464 |
Product Specific Information
This antibody detects endogenous levels of total SH3PXD2A.
Target Information
SH3PXD2A is an adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation, and the invasiveness of certain cancer cells. It binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs), and phosphoinositides. Acts as an organizer protein enabling NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and localization. In association with ADAM12, it mediates the neurotoxic effect of amyloid-beta peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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