Thermo Fisher Scientific CD42b Monoclonal Antibody (MB45), FITC
인간 CD42b 항원을 인식하는 MB45 클론 단일클론 항체로, FITC 형광 표지되어 유세포분석에 적합합니다. 높은 형광 효율과 수용성을 가지며, 혈소판 활성 및 응고 연구에 활용됩니다. 4°C 암소 보관, PBS/BSA/sucrose 완충액에 용해된 액상 형태입니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: Assay-Dependent
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MB45 |
| Immunogen | Human CD42b |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with 4 mg/mL BSA, 10% sucrose |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10375158 |
Additional Formats
- PE conjugate: MHCD42B04
- Custom conjugation available: Request Form
Product Specific Information
FITC conjugates provide high absorptivity, excellent fluorescence quantum yield, and good water solubility, making them suitable for flow cytometry and fluorescence applications.
Target Information
CD42b is a platelet activation marker involved in coagulation and platelet aggregation. It interacts with extracellular matrix and adhesion molecules, and its expression is regulated by VEGF and PDGF.
CD42b forms part of the GPIb-IX-V receptor complex, essential for platelet-rich thrombus formation by tethering platelets to thrombogenic surfaces. It binds to von Willebrand factor (VWF), thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin.
The extracellular domain contributes to metastasis, and CD42b is expressed on platelets and megakaryocytes in bone marrow. Mutations and polymorphisms in CD42b are associated with Bernard-Soulier syndrome and platelet-type von Willebrand disease.
Analyte Specific Reagent
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