Thermo Fisher Scientific Ion GeneStudio S5 Prime System, 1 system

Ion GeneStudio™ S5 Prime System

The Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system designed for simple targeted sequencing workflows. It supports high-throughput sequencing for clinical research and various applications, from microbial genomes and gene panels to exomes and transcriptomes.

Key Features

• Selectable Ion 510–550 chips for 2–130 million reads per run
• Cartridge-based plug-and-play reagents reduce setup time and complexity
• Complete run and analysis within hours
• Scalable throughput for small to large projects
• Compatible with Ion Chef™ and Ion AmpliSeq™ technologies for streamlined workflow

Ion GeneStudio S5 Series Overview

The Ion GeneStudio S5 Series includes:

• Ion GeneStudio S5 System
• Ion GeneStudio S5 Plus System
• Ion GeneStudio S5 Prime System

The main difference among these instruments is the on-sequencer analysis time.

Speed

Utilizing semiconductor sequencing technology, the system delivers high-quality sequencing data within hours. When paired with the Ion Chef System, users can go from DNA library to data in as little as 24 hours with only 45 minutes of hands-on time.

Simplicity

With single-day installation, an intuitive interface, and cartridge-based reagents, the Ion GeneStudio S5 Series is easy to operate. Integration with:

• Ion AmpliSeq technology
• Ion Chef System
• Ion Reporter Software

enables automated variant annotation and simplified targeted sequencing.

Small Sample Input

Capable of using as little as 1 ng of input DNA or RNA, suitable for challenging samples such as:

• FFPE tissue
• Fine needle aspirates
• Cell-free DNA (cfDNA)

Scalability

The Ion 5 Series chips provide multiple throughput options, allowing flexible scaling from small to large sequencing projects on a single instrument.

Simple Analysis and Storage Solutions

• Torrent Suite Software: Plan, monitor, track, and analyze sequencing runs (pre-installed on Torrent Server)
• Ion Reporter Software: Integrate, annotate, and interpret variants (available via Thermo Fisher Cloud or local installation)

Services and Support

Thermo Fisher Scientific offers extensive global support with over 2,000 field personnel, including:

• Service and support plans: Maximize instrument performance
• Qualification services: Ensure installation and operational compliance
• Training programs: Cover experimental design, troubleshooting, and instrument operation
• Bioinformatics support: Tailored NGS informatics assistance
• DataSafe Solution: Data storage and backup strategy

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