Thermo Fisher Scientific SRPK2 Polyclonal Antibody
상품 옵션 정보 | ||||||||
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
BS-7923R | - | Thermo Fisher Scientific BS-7923R SRPK2 Polyclonal Antibody 100 ul pk | 재고문의 | pk | 533,000원 | - | 586,300원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Immunohistochemistry (Paraffin) (IHC (P))
1:100-1:500
Immunohistochemistry (Frozen) (IHC (F))
1:100-1:500
Immunocytochemistry (ICC/IF)
1:50-1:200
ELISA (ELISA)
1:500-1:1,000
Product Specifications
Species Reactivity
Human, Mouse, Rat
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SRPK2, amino acids 266-350. if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
SRPK2,
uniProtId:
P78362-1,
ncbiNodeId:
9606,
antigenRange:
266-350,
antigenLength:
688,
antigenImageFileName:
BS-7923R_SRPK2_P78362-1_Rabbit.svg,
antigenImageFileNamePDP:
BS-7923R_SRPK2_P78362-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
SRPK2, along with SRPK1, is most likely the cellular protein kinase mediating HBV core protein phosphorylation during viral infection. It therefore represents an important host cell target for therapeutic intervention in HBV infection. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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