Thermo Fisher Scientific TPMT Monoclonal Antibody (1D4)
TPMT 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 1D4). Western blot, ICC/IF, ELISA에 적합. 인체 반응성, 비결합형 액상 포맷. Affinity chromatography로 정제, PBS buffer에 보존. 연구용으로만 사용 가능.
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Thermo Fisher Scientific TPMT Monoclonal Antibody (1D4)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D4 |
| Immunogen | TPMT (AAH05339, 1–245 a.a) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of TPMT protein:
MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK
SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV
FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY
LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEKTarget Information
TPMT (Thiopurine S-methyltransferase) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.
Defects in TPMT cause TPMT deficiency, affecting metabolism of thiopurine drugs used as immunosuppressants or cytotoxic agents.
Patients with reduced TPMT activity risk toxicity under standard dosing due to genetic variation at the TPMT locus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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