Thermo Fisher Scientific IP3 Receptor 2 Polyclonal Antibody
IP3 Receptor 2를 인식하는 Rabbit Polyclonal Antibody로, IHC, ICC/IF, Flow Cytometry, Dot blot 등에 사용 가능. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:50–1:100 |
| Dot blot (DB) | 1:2,000–1:5,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human ITPR2 aa 1100–1450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932570 |
Target Information
Inositol 1,4,5-trisphosphate (IP3) acts as a second messenger for various growth factors, hormones, and neurotransmitters. Upon binding to IP3R, IP3 triggers the release of intracellular calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of approximately 240 kDa glycoprotein subunits. IP3R is structurally and functionally related to the ryanodine receptor, another intracellular calcium-release channel. Both receptors can associate with the immunophilin protein FKBP12.
Phosphorylation of IP3R by PKC enhances IP3-mediated calcium release, while dephosphorylation by calcineurin reduces it, leading to calcium oscillations. Mammalian IP3R subunits are encoded by three distinct genes with differential expression:
- IP3R-I: heart, liver, kidney, ovary, cerebellar Purkinje neurons
- IP3R-II: predominantly in brain
- IP3R-III: pancreatic islets, kidney, gastrointestinal tract
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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