Thermo Fisher Scientific PCGF6 Polyclonal Antibody

Thermo Fisher Scientific PCGF6 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: TQPLYNISAN EGTGHFKPLE KKFVRVSGEA TIGHVEKFLR RKMGLDPACQ
• For short term use, store at 2–8°C up to 1 week.
• For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology: Human 100%

Target Information

Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes. Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins.
The RING-type zinc finger motif is present in many viral and eukaryotic proteins and consists of a conserved cysteine-rich domain capable of binding two zinc atoms.
Proteins containing this conserved domain are generally involved in the ubiquitination pathway of protein degradation.

PCGF6 (polycomb group ring finger 6), also known as MBLR or RNF134, is a 350 amino acid nuclear protein that is ubiquitously expressed and contains one RING-type zinc finger.
PCGF6 acts as a transcriptional repressor and regulates histone H3K4Me3 levels by activating SmcY histone demethylase.
PCGF6 exists as two alternatively spliced isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.