Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (AD4(15)), FITC
Flow Cytometry용 Mouse CD8 alpha 단클론 항체(FITC 결합). Mouse 반응성, IgM 아이소타입. 액상 형태로 0.1 mg/mL 농도, PBS+BSA 버퍼에 저장. CD8 신호전달 및 T세포 활성화 연구에 적합.
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Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (AD4(15)), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution: 2.0 µg/1x10^6 cells
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AD4(15) |
| Immunogen | C57BL/6 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles. Store in the dark. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539194 |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family, plays an integral role in signal transduction, and T cell differentiation and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
It is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Engagement of MHC-I/peptide complexes triggers Lck kinase recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs play a crucial role in pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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