Thermo Fisher Scientific cKit Polyclonal Antibody, Biotin
Biotin으로 표지된 Thermo Fisher Scientific cKit 폴리클로날 항체로, 인간 및 다양한 종에서 반응성을 보이며 WB, ELISA, IP 등에 사용 가능. Affinity chromatography로 정제된 고품질 항체로, 연구용으로 세포 신호전달 및 KIT 관련 질환 연구에 적합.
- 카탈로그번호
- CKIT-121-BIOTIN
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific cKit Polyclonal Antibody, Biotin
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Non-human primate, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 915–965 on human Tyrosine-Kinase c-Kit protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for mast cell growth factor (MGF), also known as stem cell factor (SCF). It was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT and its ligand regulate growth and activation of various hematopoietic and non-hematopoietic cells.
Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Deregulation of KIT receptor tyrosine kinase by activation loop mutation D816V is a key target in therapeutic strategies for neoplastic mast cell growth.
c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells, and gastrointestinal tract Cajal cells. Upon ligand binding, c-Kit dimerizes, leading to receptor activation and autophosphorylation of tyrosine residues, including Tyr703. This enables Grb2 docking and activation of the Ras/ERK pathway. SCF/c-Kit signaling also activates PI3K, PLC-γ, and JAK/STAT pathways, essential for hematopoiesis, stem cell maintenance, and gametogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- CKIT-121-BIOTIN_c-Kit_CD117_P10721-1_Rabbit.svg
- CKIT-121-BIOTIN_c-Kit_CD117_P10721-1_Rabbit_PDP.jpeg
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