Thermo Fisher Scientific SCO1 Polyclonal Antibody
Thermo Fisher Scientific의 SCO1 폴리클로날 항체로 인간 SCO1 단백질을 인식합니다. Western blot과 IHC(P)에서 검증된 항체이며, 항원 친화 크로마토그래피로 정제되었습니다. 비결합형 액상 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SCO1. Recombinant protein control fragment (Product #RP-93316). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647020 |
Product Specific Information
Immunogen sequence:
TREEVDQVAR AYRVYYSPGP KDEDEDYIVD HTIIMYLIGP DGEFLDYFGQ NKRKGEIAAS IATHMRPYR
Highest antigen sequence identity to orthologs:
- Mouse: 86%
- Rat: 86%
Target Information
Synthesis of cytochrome c oxidase 1 (SCO1) was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of the cytochrome c holoenzyme. This complex catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane.
Like their yeast homologs, the functions of both SCO1 and SCO2 depend on copper ion binding. Mutations in either gene can cause cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with fatal neonatal hepatopathy when the second allele is non-functional. This suggests the pathology is due to loss of function, possibly from altered SCO1 affinity for copper (I) ions, impairing copper transfer efficiency to cytochrome c oxidase.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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