Thermo Fisher Scientific TERT Monoclonal Antibody (3H2G9)
인간 TERT 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, WB, IHC, Flow, ELISA 등 다양한 응용 가능. 고순도 Protein G 정제 및 1 mg/mL 농도로 제공. 세포 노화 및 텔로머레이스 연구용에 적합.
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Thermo Fisher Scientific TERT Monoclonal Antibody (3H2G9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3H2G9 |
| Immunogen | Purified recombinant fragment of human TERT (AA: 1029–1132) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091005 |
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG.
The enzyme consists of a protein component with reverse transcriptase activity (encoded by the TERT gene) and an RNA component that serves as a template for telomere repeat synthesis.
Telomerase expression is normally repressed in postnatal somatic cells, leading to progressive telomere shortening and cellular senescence. Deregulation of telomerase expression may contribute to oncogenesis.
Studies in mouse indicate telomerase may also participate in chromosomal repair through de novo synthesis of telomere repeats at double-stranded breaks.
Multiple alternatively spliced variants of TERT have been identified, with some full-length sequences yet to be determined. Alternative splicing at this locus may regulate telomerase activity.
Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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