Thermo Fisher Scientific PI4K2A Polyclonal Antibody
PI4K2A 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합. Human 및 Mouse에 반응하며, Protein G로 정제된 액상 형태. 세포 성장 및 신호전달 연구에 활용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 1–30 amino acids from the N-terminal region of human PI4K2A (PI4K II) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2163898 |
Target Information
PI4K2A (PI4K2 alpha) lipid kinase or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositol polyphosphates (PtdInsPs), which play central roles in biological processes such as cell growth, actin cytoskeleton organization, and endo/exocytosis.
PI4K2A phosphorylates PtdIns at the D-4 position, an essential step in PtdInsPs biosynthesis.
It acts as a novel regulator of tumor growth through angiogenesis and HIF-1alpha regulation.
PI4K2A generates PtdIns4P-rich domains within the Golgi, regulating clathrin adaptor AP-1 complex targeting, and is required for Wnt-mediated LRP6 phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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