Thermo Fisher Scientific Arevirumab-3 Humanized Recombinant Human Monoclonal Antibody

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Species Reactivity

Virus

Host/Isotype

Human / IgG1, kappa

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Immunogen

Recombinant LASV GPC.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Product Specific Information

Compatible with Direct ELISA

Target Information

Arevirumab-3, also known as Arevirumab, is a broadly neutralizing human monoclonal antibody developed to treat advanced stages of Lassa virus infections. Lassa virus (LASV) is an enveloped, segmented RNA virus belonging to the family Arenaviridae, genus Mammarenavirus. It is classified within the Old World mammarenaviruses which include other viruses like the lymphocytic choriomeningitis virus, Mopeia virus, and Lujo virus. LASV circulates predominantly in West and Central Africa and has been causing zoonotic infections in humans for centuries, primarily transmitted through contact with the urine or feces of infected rodents. The virus is responsible for Lassa fever, a severe viral hemorrhagic fever (VHF) with a significant case-fatality rate among hospitalized patients, reported to be around 20% or higher. Of those infected, approximately 80% exhibit mild or no symptoms, while the remaining 20% progress to severe disease necessitating hospitalization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.