Thermo Fisher Scientific TRPM4 Polyclonal Antibody
TRPM4 단백질을 인식하는 Rabbit Polyclonal 항체로, WB와 IHC에 사용 가능. Mouse 및 Rat 시료 반응성. 동결건조 형태로 제공되며, 재구성 후 사용. 세포 내 칼슘 신호 조절 및 T세포 활성화 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse TRPM4 conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TRPM4
Target Information
Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization.
While it is activated by an increase in intracellular Ca²⁺, it is impermeable to it.
Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization.
Plays a central role in:
- Cardiomyocytes
- Neurons from entorhinal cortex, dorsal root, and vomeronasal neurons
- Endocrine pancreas cells
- Kidney epithelial cells
- Cochlea hair cells
Participates in T-cell activation by modulating Ca²⁺ oscillations after activation, required for NFAT-dependent IL2 production.
Involved in myogenic constriction of cerebral arteries and controls insulin secretion in pancreatic beta-cells.
May contribute to pacemaking or irregular electrical activity under Ca²⁺ overload conditions.
Affects Th1 and Th2 cell motility and cytokine production via regulation of calcium signaling and NFATC1 localization.
Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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