Thermo Fisher Scientific Mouse IL-1 beta, Animal-Free Recombinant Protein, PeproTech
동물 유래 성분이 없는 Mouse IL-1β 재조합 단백질로, E. coli에서 발현된 고순도(≥98%) 단백질입니다. 염증 반응 관련 연구에 적합하며, 높은 생물학적 활성(≥5×10^8 units/mg)을 보유합니다. 상온 배송 및 -20°C 보관이 권장됩니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to related publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Mouse |
| Published species | Human, Mouse |
| Expression System | E. coli |
| Amino Acid Sequence | MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS |
| Molecular Weight | 17.5 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% (SDS-PAGE, HPLC) |
| Endotoxin Concentration | < 0.1 EU/µg |
| Activity | ED50 ≤ 0.002 ng/ml (≥ 5 × 10^8 units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Murine IL-1β is a 17.5 kDa protein containing 153 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into the active 17 kDa form through inflammasome activation.
IL-1β lacks a classical signal peptide and is secreted via a noncanonical pathway. It signals through IL-1RI and IL-1RII receptors, shared with IL-1α, and its activity is regulated by IL-1 Receptor Antagonist (IL-1RA).
IL-1β plays a critical role in innate immune defense by inducing other proinflammatory cytokines and acute-phase responses. Elevated IL-1β levels are linked to chronic inflammatory diseases, making IL-1β neutralization a potential therapeutic strategy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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