Thermo Fisher Scientific NMT2 Monoclonal Antibody (OTI1B4)

Applications and Tested Dilution

Product Specifications

Target Information

Proteolytic degradation is essential for maintaining proper levels of short-lived and regulatory proteins, including those involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling. The ubiquitin-proteasome pathway degrades most proteins in the eukaryotic cytosol and nucleus, while others are processed via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit molecular machine (~2.5 MDa), composed of a 20S proteolytic core complex and 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S lumen. Ubiquitin molecules are attached to target proteins through an enzymatic cascade. Defects in this pathway are associated with genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.