Thermo Fisher Scientific PGGT1A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

FNTA (Farnesyltransferase, CAAX box; alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/geranyl geranyl transferase type I alpha subunit (PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located at locus 8p11 (human).

Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The best characterized among these is the CAAX farnesyl transferase (EC 2.5.1.21), an alpha-beta heterodimeric enzyme that catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C-terminus of proteins ending in the CAAX box.

FNTA, the alpha subunit of farnesyl transferase, is shared by geranyl-geranyl protein transferases. In addition to transferring farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras. Reports have shown that FNTA interacts with TGF-beta and activin-type I receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.