Thermo Fisher Scientific PDE8B Polyclonal Antibody
Rabbit polyclonal antibody against human PDE8B, validated for ICC/IF applications. Antigen affinity purified and supplied in PBS with 40% glycerol. Suitable for research use only, offering high specificity and stability for cAMP signaling studies.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PDE8B. Recombinant protein control fragment (Product #RP-105930) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2662279 |
Product Specific Information
Immunogen sequence:
RRHCCSSAEAE TQTCYTSVKQ VSSAEVRIGP MRLTQDPIQV LLIFAKEDSQ SDGFWWACDR AGYRCNIART PESALECFLD
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 62%
Target Information
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5′,3′-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5′-monophosphates. Mammalian PDEs are grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies.
The PDE8 family contains high-affinity cAMP-specific, IBMX-insensitive PDEs, such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain responsible for distinct regulatory properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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