Thermo Fisher Scientific PSMA1 Monoclonal Antibody (10A2)

Applications 및 Dilutions

Product Specifications

Target Information

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, heat shock and stress response, antigen presentation, cell surface receptor modulation, ion channel regulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cytosol and nucleus, while others are degraded via the vacuolar pathway (endosomes, lysosomes, endoplasmic reticulum).
The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular complex (~2.5 MDa) consisting of a 20S proteolytic core and one or two 19S regulatory subunits.
The 19S subunits recognize ubiquitinated proteins and assist in their unfolding and translocation into the 20S core.
Defects in this pathway are linked to several genetic diseases, including cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: BSM-54170R_PSMA1_P25786-1_Rabbit.svg, BSM-54170R_PSMA1_P25786-1_Rabbit_PDP.jpeg)