Thermo Fisher Scientific CCDC134 Polyclonal Antibody
인간, 마우스, 랫트에 반응하는 Rabbit Polyclonal 항체로, CCDC134 단백질을 인식합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, 단백질 A로 정제된 고순도 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human CCDC134, amino acids 11–120 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The coiled-coil domain is a common protein motif often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments.
CCDC134 is a secretory protein known to inhibit the transcriptional activity of the Elk1 protein. Overexpression of CCDC134 inhibits phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while siRNA against CCDC134 activates Elk1 transcriptional activity and phosphorylation of Erk and JNK/SAPK.
These findings suggest that CCDC134 may play an inhibitory role in MAPK-mediated Elk1 transcription. CCDC134 is widely expressed in normal adult tissues, tumors, and cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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