Thermo Fisher Scientific WWC1 Monoclonal Antibody (OTI1B1), TrueMAB
인간 WWC1 단백질을 인식하는 단클론 항체로 Western blot에 최적화됨. TrueMAB 포맷의 마우스 IgG1 항체. 동결건조 형태로 제공되며, 높은 순도의 친화 크로마토그래피 정제 제품. Hippo 신호 경로 연구 및 단백질 발현 분석에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B1 |
| Immunogen | Full length human recombinant protein of human WWC1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway, which plays a key role in tumor suppression by limiting proliferation and promoting apoptosis.
WWC1, together with NF2, can synergistically induce phosphorylation of LATS1 and LATS2.
It acts as a transcriptional coactivator of ESR1, essential for DYNLL1-mediated ESR1 transactivation, and regulates collagen-stimulated activation of the ERK/MAPK cascade.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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