Thermo Fisher Scientific UGT1A4 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: VVLTPEVNMH IKEEKFFTLT AYAVPWTQKE FDRVTLGYTQ GFFETEHLLK
• Sequence homology: Human: 100%

Target Information

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules such as steroids, bilirubin, hormones, and drugs into water-soluble, excretable metabolites. The gene locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are pseudogenes, and the remaining nine may be spliced to the common exons, resulting in nine proteins with distinct N-termini and identical C-termini. Each first exon encodes the substrate binding site and is regulated by its own promoter. This enzyme exhibits glucuronidase activity towards bilirubin and is more active on amines, steroids, and sapogenins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.