Thermo Fisher Scientific SLA Polyclonal Antibody
Rabbit polyclonal antibody against human SLA protein. Validated for ICC/IF applications. Affinity purified and supplied in PBS with 40% glycerol. Suitable for research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human SLA. Recombinant protein control fragment (Product #RP-107983) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663230 |
Product Specific Information
Immunogen sequence:
PCLTQSTAAPA VRASSSPVTL RQKTVDWRRV SRLQEDPEGT ENPLGVDESL FSYGLRESIA SYLSLTSEDN TSFDRKKKSI SLMYGGSKRK SSFFSSPP
Highest antigen sequence identity to the following orthologs:
- Mouse: 73%
- Rat: 71%
Target Information
SLAP (Src-like-adapter protein 1) is a 276-amino-acid adapter protein acting as a negative regulator of T-cell receptor (TCR) signaling. Belonging to the SRC family of cytoplasmic tyrosine kinases, it contains SH2 and SH3 domains. SLAP colocalizes with endosomes and inhibits T-cell antigen receptor-induced activation of nuclear factor of activated T-cells. It functions as a negative regulator of positive selection and mitosis of T-cells, possibly by linking signaling proteins such as ZAP70 with CBL, leading to CBL-dependent degradation of signaling proteins. Expression is weak in heart, adult brain, placenta, liver, skeletal muscle, kidney, and pancreas, but high in lung and fetal brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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