Thermo Fisher Scientific SLA Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human SLA. Recombinant protein control fragment (Product #RP-107983). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SLA,uniProtId:Q13239-1,ncbiNodeId:9606,antigenRange:174-272,antigenLength:276,antigenImageFileName:PA5-67335_SLA_Q13239-1_Rabbit.svg,antigenImageFileNamePDP:PA5-67335_SLA_Q13239-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663230

Product Specific Information

Immunogen sequence: PCLTQSTAAPA VRASSSPVTL RQKTVDWRRV SRLQEDPEGT ENPLGVDESL FSYGLRESIA SYLSLTSEDN TSFDRKKKSI SLMYGGSKRK SSFFSSPP

Highest antigen sequence identity to the following orthologs - mouse 73%, rat 71%.

Target Information

SLAP also known as Src-like-adapter protein 1 is a 276 amino acid containing adapter protein, functioning as a negative regulator of T-cell receptor (TCR) signaling. SLAP belonging to the SRC family of cytoplasmic tyrosine kinases contains a SH2 domain and a SH3 domain. This cytoplasmic protein colocalizes with endosomes and is known to inhibit T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. It acts as a negative regulator of positive selection and mitosis of T-cells. SLAP may act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Expression of SLAP is weak in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas but is high in lung and fetal brain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.