Thermo Fisher Scientific LIN7C Polyclonal Antibody
LIN7C 단백질을 표적하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. Human 시료에 반응하며, 합성 펩타이드 면역원으로 제작되었습니다. 액상 형태로 제공되며, -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human LIN7C (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576987 |
Product Specific Information
Peptide sequence:
MAALGEPVRL ERDICRAIEL LEKLQRSGEV PPQKLQALQR VLQSEFCNAV
Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 93%
Target Information
Protein assembly at the postsynaptic density (PSD) of neuronal synapses is mediated in part by protein interactions with PDZ (PSD-95/discs large/zona occludens-1) motifs.
The Mammalian LIN-7 (MALS) proteins are a family of small synaptic proteins that are the mammalian homologs of LIN-7, a C. elegans protein essential for vulval development.
MALS proteins are also known as Veli (Vertebrate Lin-7) proteins. MALS-3 mRNA is most abundant in kidney, followed by brain, liver, thymus, and heart, but undetectable in spleen.
In cultured cortical neurons, MALS proteins cluster with PSD-95 and NMDA-type glutamate receptors. They are suggested to regulate recruitment of neurotransmitter receptors to the PSD and assembly of proteins involved in synaptic vesicle exocytosis and synaptic junctions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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