Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI5C5)
N4BP2L2 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단일클론 항체입니다. IHC(P)에서 1:150 희석으로 검증되었으며, 인간 시료에 반응합니다. 고순도 친화 크로마토그래피로 정제된 액상 항체로, 안정적 PBS 버퍼에 보존됩니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C5 |
| Immunogen | Full length human recombinant protein of N4BP2L2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723388 |
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation. It is phosphorylated on Ser 199 in response to DNA damage, likely by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is dramatically down-regulated after exposure to arsenic compounds, an event that precedes neutropenia. PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, proteins implicated in neutropenia disorders. Defects in the ELA2 gene (encoding Neutrophil Elastase) cause cyclic haematopoiesis, characterized by decreased neutrophil counts and increased susceptibility to infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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