Thermo Fisher Scientific PTRF Polyclonal Antibody
Thermo Fisher Scientific의 PTRF Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 WB, IHC, ICC, ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5110243
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 200–280 of human PTRF (NP_0363642) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855654 |
Product Specific Information
Immunogen sequence:
ELSSDEAVEV EEVIEESRAE RIKRSGLRRV DDFKKAFSKE KMEKTKVRTR ENLEKTRLKT KENLEKTRHT LEKRMNKLGT R
Target Information
The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3′ end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and plays a critical role in caveolae formation and caveolin stabilization, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is implicated in lipid metabolism and insulin-regulated gene expression. Mutations in this gene are associated with generalized lipodystrophy and muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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