Thermo Fisher Scientific PGP9.5/UchL1 (pan-Neuronal Marker) Monoclonal Antibody (rUCHL1/8133)
PGP9.5/UchL1 단백질을 인식하는 pan-neuronal 마커 항체로, 인간 시료에 반응합니다. WB, IHC, ICC, Flow 등 다양한 응용 가능. 단일클론 마우스 IgG2a 항체이며, 액상 형태로 제공. 신경세포 및 신경퇴행성 질환 연구에 적합.
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Thermo Fisher Scientific PGP9.5/UchL1 (pan-Neuronal Marker) Monoclonal Antibody (rUCHL1/8133)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rUCHL1/8133 |
| Immunogen | Recombinant full-length human UCHL1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PGP9.5 (Protein gene product 9.5, also known as UCH-L1 or PARK5) is a neuron-specific protein distinct from neuron-specific enolase. It has a molecular weight of 27 kDa and is part of the ubiquitin carboxyl-terminal hydrolase family (peptidase family C12). PGP9.5 exhibits both ubiquitin hydrolase and ligase activities, generating ubiquitin monomers from small C-terminal adducts.
PGP9.5 is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, as well as in neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, and ovarian tissues. Overexpression is associated with non-small cell lung cancer, while reduced expression is linked to Huntington’s and Alzheimer’s diseases. Due to its presence in neuronal inclusions, PGP9.5 serves as a valuable neuronal marker for studies on neurodegenerative disorders such as Parkinson’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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