
Thermo Fisher Scientific LRP6 Polyclonal Antibody
Rabbit polyclonal antibody targeting human LRP6 for Wnt/β-catenin signaling research. Unconjugated, liquid form, 0.2 mg/mL concentration. Suitable for various immunoassays. For research use only.
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Thermo Fisher Scientific LRP6 Polyclonal Antibody
제품 사양
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LRP6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790270 |
Product Specific Information
Immunogen sequence:
GALRCNGDAN CQDKSDEKNC EVLCLIDQFR CANGQCIGKH KKCDHNVDCS DKSDELDCYP TEEPAPQ
Target Information
LRP6 is essential for the Wnt/β-catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/β-catenin signaling via LRP6 removal through Kremen proteins-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 제품 관련 이미지: PA5-83114_LRP6_O75581-1_Rabbit.svg, PA5-83114_LRP6_O75581-1_Rabbit_PDP.jpeg)
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