Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (OTI1G1), TrueMAB
Beta-catenin 단백질을 인식하는 Mouse monoclonal antibody로, Western blot, IHC, Flow cytometry에 적합. Human 및 Dog 반응성. 고순도 Affinity chromatography 정제. 세포 성장 및 신호전달 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G1 |
| Immunogen | Full length human recombinant protein of human CTNNB1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Beta-catenin is an adherens junction (AJ) protein identified as a component of cell-cell adhesion structures. AJs are essential for the formation and maintenance of epithelial cell layers by regulating cell growth and adhesion. Beta-catenin interacts with E-cadherin and alpha-catenin, anchoring the E-cadherin complex to the cortical actin cytoskeleton. It also binds to cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, and participates in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless.
Beta-catenin is expressed in various hair follicle cell types and plays a role in morphogenesis and tumorigenesis. Pathological roles have been identified in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and other solid tumors. In the nucleus, it co-activates Lef/Tcf transcription factors, stimulating genes such as cyclin D and c-myc that promote cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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