Thermo Fisher Scientific EXOSC5 Polyclonal Antibody
Thermo Fisher Scientific의 EXOSC5 Polyclonal Antibody는 인간 Exosome Component 5의 N-말단(1–50 aa) 영역을 면역원으로 한 토끼 다클론 항체입니다. Western blot 및 Immunoprecipitation에 최적화되어 있으며, 1 mg/mL 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human Exosome Component 5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Non-catalytic component of the RNA exosome complex which has 3′→5′ exoribonuclease activity and participates in multiple RNA processing and degradation events.
In the nucleus, it is involved in maturation of stable RNA species (rRNA, snRNA, snoRNA), elimination of RNA processing by-products and non-coding pervasive transcripts, and degradation of defective mRNAs to prevent their cytoplasmic export.
It may also play a role in Ig class switch recombination (CSR) and somatic hypermutation (SHM).
In the cytoplasm, it contributes to mRNA turnover, degradation of AU-rich element-containing mRNAs, and RNA surveillance pathways, including histone mRNA degradation.
The catalytic inactive RNA exosome core complex (Exo-9) serves as a scaffold for RNA binding and interaction with catalytic subunits and accessory proteins.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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