Thermo Fisher Scientific FGFR1 Monoclonal Antibody (OTI5D5), TrueMAB
Human FGFR1 단백질(aa 1-376)을 항원으로 제작된 Mouse IgG1 단일클론 항체. Western blot에 최적화되어 있으며, 액상 형태로 제공. PBS/BSA/glycerol buffer에 보관하며 -20°C에서 안정적 유지. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–376 of human FGFR1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases acting as high-affinity receptors for 17 growth factors (FGF1–17).
These receptors play key roles in biological processes such as mesoderm induction, cell growth and migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, resulting in multiple variants expressed differently during embryonic and adult stages.
Mutations or chromosomal aberrations in FGFR1 are associated with several disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal abnormalities involving FGFR1 have also been linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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