Thermo Fisher Scientific FOXO1 Polyclonal Antibody
FOXO1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, Flow cytometry에 사용 가능. 고순도 정제 및 액상 형태로 제공되며, 인간 단백질에 반응하고 소, 돼지에도 예측 반응. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 454–482 of human FKHR (FOXO1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2106486 |
Product Specific Information
This antibody is predicted to react with bovine and porcine species based on sequence homology.
Target Information
FOXO1 (FKHR, Forkhead Box O1) is a transcription factor belonging to the forkhead family. It can function as a coactivator or corepressor of nuclear receptor activity via the LXXLL motif in the C-terminal region. FOXO1 interacts with PAX3 and is implicated in alveolar rhabdomyosarcoma. It plays roles in autophagy, myogenic differentiation, and tumor suppression.
FOXO1 is a key regulator in insulin signaling, metabolic homeostasis, and oxidative stress response. It binds to insulin response elements (IRE) and Daf-16 family binding elements (DBE), controlling redox balance, osteoblast number, and bone mass. In hepatocytes, FOXO1 promotes gluconeogenesis by activating genes such as IGFBP1, G6PC, and PPCK1 in cooperation with PPARGC1A. It also regulates glucose metabolism and suppresses RUNX2 activity, influencing osteocalcin expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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