Thermo Fisher Scientific Histone H2A.X Polyclonal Antibody
Histone H2A.X 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC, IP 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공.
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Thermo Fisher Scientific Histone H2A.X Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:20,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 3 publications |
| Immunoprecipitation (IP) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 80–143 of Human Histone H2A.X |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.41 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546254 |
Product Specific Information
- Recommended positive controls: 293T, HepG2, HCT116, HCT116 (30uM cisplatin for 24hr), Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, mouse brain, rat brain, PC-12, Rat2, 4T1
- Predicted reactivity: Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Histone H2A.X (H2AX) is a member of the histone H2A family, one of the four core histones forming the nucleosome core particle. In eukaryotes, DNA double-strand breaks (DSBs) trigger phosphorylation of serine 139 at the carboxy terminus of H2AX, resulting in gamma-H2AX formation. This phosphorylation can be detected by Western blot or immunofluorescence, indicating DSB frequency.
Phosphatidylinositol 3-kinases are implicated in H2AX phosphorylation, though it remains uncertain whether ATM is the primary kinase or if DNA-PK and ATR also contribute.
H2A.X contains 143 amino acids and is synthesized during G1 and S-phase. Its mRNA exists in two forms — one (~1600 bases) with polyA tail and another (~575 bases) without — corresponding to basal and replication-type histones, respectively.
Histone H2A.X maps to the 11q23.2–q23.3 region of the human chromosome and contributes to DNA structure and repair by mediating MDC1 binding at DNA damage sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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