Thermo Fisher Scientific MPP5 Polyclonal Antibody
MPP5 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P)에서 사용 가능. 인간, 생쥐, 랫트 반응성. Affinity chromatography로 정제된 액상 항체로, PBS/glycerol buffer에 보존. 세포 극성 및 신경 발생 연구에 적합.
- 카탈로그번호
- PA599990
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MPP5 (Accession Q8N3R9), corresponding to amino acid residues S588–Y638 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818923 |
Product Specific Information
This antibody detects endogenous levels of total MPP5.
Target Information
MPP5 (Membrane Protein, Palmitoylated 5) is essential for neurogenesis and hematopoiesis. It plays a key role in establishing and maintaining cell polarity in epithelial cells and neurons. MPP5 is a component of the Par-3 complex, contributing to tight junction maintenance in epithelial cells.
Mutations in MPP5 are linked to severe neurological impairments such as global developmental delay (GDD) and behavioral changes. In animal models, MPP5 is involved in the early differentiation of multipotent progenitors and supports long-term lineage-specific contributions, mainly in myeloid and lymphoid cells. Variants of MPP5 disrupt normal cellular function, leading to developmental and functional abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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