Thermo Fisher Scientific LDB3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Predicted to react with canine, mouse, porcine, and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 1,000.

Target Information

The LDB3 gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein–protein interaction domains consisting of 80–120 amino acid residues. These proteins interact in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins.
The encoded protein interacts with alpha-actinin-2 via its N-terminal PDZ domain and with protein kinase C through its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50–60 amino acids containing two zinc-binding modules.
This protein also interacts with all three members of the myozenin family. Mutations in this gene have been linked to myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains, while only longer isoforms (1, 2, and 5) possess C-terminal LIM domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.