Thermo Fisher Scientific DKK3 Polyclonal Antibody
Goat 폴리클로날 항체로 DKK3 단백질을 검출. IHC(P)에서 3.8 µg/mL로 테스트됨. Peptide ELISA에서 높은 민감도(1:16,000 희석 한계). 비결합형 액상 형태로 -20°C 보관. 연구용으로만 사용.
- 판매단위
- pk
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Thermo Fisher Scientific DKK3 Polyclonal Antibody
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 3.8 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence TLSVVGPHPKPCIL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and two conserved cysteine-rich domains separated by a linker region. Each domain contains 10 cysteine residues. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane.
The linker region contains 50–55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases.
Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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