Thermo Fisher Scientific PDE4B Monoclonal Antibody (OTI2B6), TrueMAB
PDE4B 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI2B6). Western blot, IHC, ICC/IF, Flow Cytometry에 사용 가능. Human PDE4B에 반응하며, 동결건조 형태로 제공. 연구용으로 신호전달 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B6 |
| Immunogen | Full length human recombinant protein of human PDE4B produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
When using this carrier-free antibody for conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The PDE4B gene belongs to the type IV, cyclic AMP (cAMP)-specific phosphodiesterase family. These enzymes regulate intracellular cAMP levels, which are key second messengers mediating cellular responses to hormones, light, and neurotransmitters.
PDE4B specifically hydrolyzes cAMP, and altered activity of this enzyme has been associated with schizophrenia and bipolar affective disorder. Multiple splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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